Most of the kidney diseases will attack the nephrons. This damage will leave the kidneys unable to remove the wastes. Causes which includes were genetic problems, obesity, injuries or medicines. You will have higher risk of the kidney disease if you are suffering with obesity, diabetes or high blood pressure or a close family member who are suffering with kidney disease. Chronic kidney diseasewill damages the nephrons gradually over several years.

Obesity & being overweight were come of the risk factors for chronic kidney disease & are associated with progression of disease. Excessive body weight is a major risk factor of end-stage renal disease (ESRD). Obesity will increases blood pressure by increasing the renal tubular sodium reabsorption, impairing the pressure natriuresis & causing the volume expansion because of the activation of sympathetic nervous system & renin-angiotensin system & by the physical compression of kidneys, particularly when the visceral obesity is present. Weight reduction is an important and essential initial step in the management of obesity, kidney disease and hypertension.